Mediterranean Diet Is Associated With Lower Probability of Prodromal Parkinson’s Disease

TAKE-HOME MESSAGE

  • A Mediterranean diet seems to delay the onset of Parkinson’s disease (PD) in an elderly population. Researchers used the Movement Disorder Society (MDS) research criteria for prodromal Parkinson’s Disease along with measuring the dietary habits of a population in Greece.
  • Eating a Mediterranean diet may result in delayed onset or lower incidence of PD.

Abstract

BACKGROUND

The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal PD.

OBJECTIVES

To assess the probability of prodromal PD in an older population and investigate its possible association with Mediterranean diet adherence.

METHODS

Data from a population-based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece were used. Probability of prodromal PD was calculated according to International Parkinson and Movement Disorder Society research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score, ranging from 0 to 55, with higher scores indicating higher adherence.

RESULTS

Median probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1,731 PD-free individuals aged ≥ 65 (41% male). Lower probability for prodromal PD (P < 0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by nonmotor markers of prodromal PD, depression, constipation, urinary dysfunction, and daytime somnolence. Each unit increase in Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (P < 0.001). Compared to participants in the lowest quartile of Mediterranean diet adherence, those in the highest quartile were associated with a ∼21% lower probability for prodromal PD.

CONCLUSIONS

Adherence to the Mediterranean diet is associated with lower probability of prodromal PD in older people. Further studies are needed to elucidate the potential causality of this association, potential relation of the Mediterranean diet to delayed onset or lower incidence of PD, as well as the underlying neurobiological mechanisms.

Citation

Maraki, Yannakoulia, Stamelou, Stefanis, Xiromerisiou, Kosmidis, Dardiotis, Hadjigeorgiou, Sakka, Anastasiou, Simopoulou, Scarmeas. Mediterranean Diet Adherence Is Related to Reduced Probability of Prodromal Parkinson’s Disease.  Mov. Disord. 2019 Jan 01;34(1)48-57

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