Vitamin E and Alzheimer’s Disease

Vitamin E and Alzheimer’s Disease

[Article in Japanese]


  • Oxidative Stress has been suggested as a causative factor in the development of Alzheimer’s disease
  • Vitamin E, an antioxideant, has been recommended in the prevention or treatment for Alzheimer’s disease.
  • Studies have demonstrated a decrease in cognative decline for Alzheimer’s patients treated with vitamin E, but no cognative improvement for patients with mild cognative impairment.
  • Further studies are needed to establish a role for vitamin E in the treatment or prevention of Alzheimer’s disease.


Vitamin E and Alzheimer's DiseaseIt has been suggested that oxidative stress may contribute to the pathogenesis of Alzheimer’s disease. Vitamin E is a potent antioxidant, and the results of some epidemiological studies have suggested that high intake of vitamin E through food is inversely associated with the incidence of Alzheimer’s disease. Randomized controlled studies have shown that treatment with vitamin E could delay functional decline in patients with mild to moderate Alzheimer’s disease. However, vitamin E had no cognitive benefits in patients with mild cognitive impairment or in generally healthy older women. Well-designed clinical trials or preventive interventions with vitamin E are necessary to establish its efficacy as therapeutic or preventive agents for Alzheimer’s disease.


Shinohara M1, Yamada M. Vitamin E and Alzheimer’s Disease.  Brain Nerve. 2015 Dec;67(12):1509-1513.

Author information:

1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science.


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