Vitamin E and Alzheimer’s Disease
[Article in Japanese]
- Oxidative Stress has been suggested as a causative factor in the development of Alzheimer’s disease
- Vitamin E, an antioxideant, has been recommended in the prevention or treatment for Alzheimer’s disease.
- Studies have demonstrated a decrease in cognative decline for Alzheimer’s patients treated with vitamin E, but no cognative improvement for patients with mild cognative impairment.
- Further studies are needed to establish a role for vitamin E in the treatment or prevention of Alzheimer’s disease.
It has been suggested that oxidative stress may contribute to the pathogenesis of Alzheimer’s disease. Vitamin E is a potent antioxidant, and the results of some epidemiological studies have suggested that high intake of vitamin E through food is inversely associated with the incidence of Alzheimer’s disease. Randomized controlled studies have shown that treatment with vitamin E could delay functional decline in patients with mild to moderate Alzheimer’s disease. However, vitamin E had no cognitive benefits in patients with mild cognitive impairment or in generally healthy older women. Well-designed clinical trials or preventive interventions with vitamin E are necessary to establish its efficacy as therapeutic or preventive agents for Alzheimer’s disease.
1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science.