Author Archive | David Schimp

The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain

Summary:Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration (IVDD) is one of the leading causes of LBP. However, the pathogenesis of IVD-related LBP is still controversial, and the treatment means are also insufficient to date. In recent...

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Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial

AbstractObjectiveTo determine what dose of melatonin is most effective for treating migraine acutely in children and adolescents.BackgroundAcute migraine medications may not work for all patients and may cause side effects. Melatonin is effective for migraine prevention in adults and has been used acutely for procedural pain in children. Our goal was to determine whether a...

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Neurological Complications Associated with the Blood-Brain Barrier Damage Induced by the Inflammatory Response During SARS-CoV-2 Infection

AbstractThe main discussion above of the novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has focused substantially on the immediate risks and impact on the respiratory system; however, the effects induced to the central nervous system are currently unknown. Some authors have suggested that SARS-CoV-2 infection can dramatically affect brain function and exacerbate...

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Associations of Psychologic Factors with Multiple Chronic Overlapping Pain Conditions

Aims: To characterize psychologic functioning across five chronic overlapping pain conditions (COPCs)-temporomandibular disorders, fibromyalgia, low back pain, headache, and irritable bowel syndrome-and their overlaps.Methods: Participants were 655 adults in the OPPERA study. Psychologic variables were standardized in separate logistic regression models to compare their relative strength of association with each COPC. Random forest regression was...

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Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014 — Implications for gout management?

Introduction: Current evidence on the association between dietary vitamin E intake and hyperuricemia risk is limited and conflicting. Objective: The aim of the study was to assess the association of dietary vitamin E intake with hyperuricemia in US adults. Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey,...

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The Cost-Effectiveness of Platelet-Rich Plasma Compared With Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis

Although a series of either PRP ($8,635.23/QALY) or HA ($5,331.75/QALY) injections for the treatment of symptomatic knee osteoarthritis would be considered cost-effective (cost per QALY < $50,000), PRP injections were not more cost-effective than HA injections. However, PRP was significantly more effective at 1 year, and being associated with an incremental cost-effectiveness ratio of $12,628.15/QALY...

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Brain Abnormalities and Tinnitus

Neuroscientists at Georgetown University Medical Center and Germany’s Technische Universität München suggest a brain abnormality may be responsible for tinnitus and for chronic pain.  The researchers postulate that neural mechanisms that normally “gate” or control noise and pain signals can become dysfunctional. Tinnitus can occur after the ears are damaged by loud noise, but even after the...

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Spinal-Cord-Stimulation

Spinal Cord Neuroplasticity

TAKE-HOME MESSAGE The spinal cord participates in the execution of skilled movements by translating signals from the cerebral cortex to the peripheral nervous system and ultimately to the muscular system. Emerging information suggests that the spinal cord does more than act as a passive relay of information from the cortex to the muscles. The spinal cord...

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TBI, Inflammation and Brain Disease

Omega – 3 Fatty Acid Supplementation Post Mild Traumatic Brain Injury

Take Home Message: Dietary supplementation with DHA (omega – 3 fatty acid) may act as a recovery aid, or possibly as a prophylactic nutritional measure, for mild traumatic brain injury. Chiropractic Neurologists engaged in the evaluation of mild traumatic brain injury/concussion may consider Omega – 3 fatty acid supplementation to be a potentially beneficial adjunct to case...

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Nutritional Supplement may Improve Symptoms of Carpal Tunnel Syndrome

From Int J Immunopathol Pharmacol TAKE-HOME MESSAGE The authors compared efficiency of shock wave therapy versus nutraceutical composed of alpha lipoic acid, conjugated linoleic acid, anti-oxidants and Echinacea angustifolia for carpal tunnel syndrome A trend to better pain regression was identified in the nutraceutical group Abstract Even though the initial treatment of carpal tunnel syndrome...

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