Migraine as a Cortical Brain Disorder

TAKE-HOME MESSAGE Migraine has been a difficult condition to fully understandAdvanced neuroimaging data and neurophysiological research indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle.Migraine disorder stems, in part, from an imbalance in inhibitory/excitatory cortical circuitsSpinal Manipulative Therapy (SMT) has been found to have an effect…

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